Simergent is presenting a poster on the Prevalence of Fluid Pressure Complications in APD Patients at ISPD 2018
Simergent is presenting a poster on the Prevalence of Fluid Pressure Complications in APD Patients at ISPD 2018 in Vancouver, Canada. Since gravity-based devices have largely been replaced with active pumping APD devices in the United States, it is unknown if the higher pumping pressures or increased intraperitoneal volumes (IIPV) associated with these devices may be leading to serious injuries or deaths. Current pump-driven APD devices deliver PD solutions at pressures up to 181 mmHg (24.1 kPa), while normal intraperitoneal pressure for PD patients is 10.3 mmHg (1.37 kPa). Increased intraperitoneal pressure (IIPP) can lead to abdominal or back pain, dialysate leakage into the abdominal wall and surrounding tissues, pleural effusions, reduced cardiac output, and shortness of breath.
The goal of this study is to quantify the frequency of complications that may be associated with excess fluid pressure in APD patients, as compared to other non-peritonitis events.
Complications related to hernias, pleural effusions, or internal fluid leaks were the greatest category of death or serious injury Medical Device Reportable (MDR) events not attributable to peritonitis, or 38.4% of all non-peritonitis death and serious injury MDRs.. Further study is warranted in assessing the role of fluid delivery pressure in active pumping versus gravity-based APD devices to determine the root cause of peritoneal membrane damage in APD patients.